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POM I Scientific Methods: Course Resources

A collection of recommended resources for the Scientific Methods section of the Practice of Medicine I
Randomized Controlled Trial Standard Deviation


Hully SB, Cummings SR, Browner WS, Grady DG, Newman TB
Designing Clinical Research


Straus SE, Glaszious P, Richardson WS, Haynes RB 
Evidence-Based Medicine. How to Practice and Teach EBM [not available electronically]


Haynes RB 
Clinical Epidemiology: How to Do Clinical Practice Research. 


Ball J, Bewick V and Cheek L  Review: Statistics review 13: Receiver operating characteristic curves.  Critical Care 2004, 8:508-512

Beswick V, Cheek L, Ball J  Review: Statistics review 8: Qualitative data- tests of association.  Critical Care 2002, 8:46-53

BorsonBorson S, Scanlan JM, Chen P, Ganguli M.  Ganguli M.  The Mini-Cog as a screen for dementia: validation in a population-based sample.  J Am Geriatr Soc 2003 51:1451-1454

Carpenter CR, Keim SM, Crossley J, Perry JJ  Post-transient ischemic attack early stroke stratification: the ABCD (2) prognostic aid.  J Emerg Med 2009;36:194-198

Carpenter CR, Keim SM, Seupaul RA, Pines JM  Differentiating low-risk and no-risk PE patients: The PERC score.  J Emerg Med  2009; 36:317-322

Carpenter CR, The San Franciso Syncope Rule did not accurately predict serious short-term outcome in patients with syncope.  Evid Based Med 2009;12:25

Chassin MR, Galvin RW  The urgent need to improve health care quality Institute of Medicine National Roundtable on Health Care Quality [see comments].  JAMA  1998 September 16;280(11):1000-1005.

Goel I and the Health Services Research Group.  Decision analysis: applications and limitations.  CMAJ August 15, 1992:147:413-417

Greenbalgh T  How to read a paper: Statistics for the non-statistician. II: "Significant" relations and their pitfalls.  BMJ 1997;315;422-25

IoannidisIoannidis JP  Why most published research findings are false.  PLoS Med  2005 August; 2 (8):e124

Loong T-W  Understanding sensitivity and specificity with the right side of the brain.  BMJ  2003;327:716-9

Murdoch TB, Detsky AS  Inevitable application of big data to health care JAMA, April 3, 2013; 309(13):1351-1352

National Institutes of Health, Data and Informatics Working Group. Draft Report to the Advisory Committee to the Director, June 15, 2012

Smith R  Communicating risk: the main work of doctors.  BMJ 2003 September  25;327 (7417)

Thornton H  Editorials: Patients' understanding of risk. BMJ 2003 September 27;327(7417):693-4

Ware M, Mabe M.  Mabe M.  The STM Report: an overview of scientific and scholarly journal publishingThe Hague, The Netherlands: International Association of Scientific, Technical and Medical Publishers; 2015.

Whitley E, Ball J  Review. Statistics review 5: Comparison of means.  Critical Care  202, 6:424-428.

Whitley E, Ball J  Review. Statistics review 6: Nonparametric Methods.   Critical Care  202, 6:509-513

Whitely E, Ball J  Review.  Statistics review 3:Hypothesis testing and P values.  Critical Care  2002, 6:222-225

Whitely E, Ball J  Review.  Statistics review 4:Sample size calculations.  Critical Care  2002, 6:335-341

Woloshin S, Schwartz LM, Ellner A  Editorials: Making sense of risk information on the web.  BMJ 2003


"Risk Talk"

  • Assess Preferences for Information
  • Discuss the Origin and Nature of the Risk Evidence
  • Numercy (Single event probabilities, conditional probabilities, natural frequencies, emphasize absolute risk reduction)
  • Explain meaning of the reference class
  • Paradox of individual risk and the inability to predict single events
  • The importance of time and the relationship between time and risk
  • Acknowledge uncertainty, role of chance, and the illusion of certainty
  • The importance of positive and negative framing, cognitive biases, and heuristics
  • Distill the gist/Recap and summarize
  • Use teachback